Degradation of Neuropeptides by Calcium-Activated Neutral Protease1
- 1 December 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 94 (6) , 2071-2074
- https://doi.org/10.1093/oxfordjournals.jbchem.a134564
Abstract
The substrate specificity of calcium-activated neutral protease (CANP) from monkey cardiac muscle was examined with various neuropeptides as substrates. The enzyme required mM order calcium ions for activation and had an enkephalinase activity, hydrolyzing Leu-enkephalin at the 1Tyr-2Gly and 3Gly-4Phe bonds. Furthermore, it showed the tendency to cleave especially the bonds around the paired basic amino acid residues in α- and β-neoendorphins and dynorphin(1-13), while it could not hydrolyze substance P.Keywords
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