Cushing's Syndrome Due to an ACTH-Secreting Chromophobe Adenoma

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Abstract
NELSON et al.1 , 2 recently described the occurrence of ACTH-secreting chromophobe adenomas in patients with adrenocortical hyperplasia after bilateral total adrenalectomy. Since then, others3 , 4 have reported similar cases, some of which showed enlargement of the sella turcica before adrenalectomy. In none of these cases, however, was the diagnosis of an ACTH-secreting chromophobe adenoma established at the outset, and the present evidence favoring a pituitary etiology is based on retrospective reasoning and demonstration of abnormally high levels of ACTH in the plasma and pituitary glands of adrenalectomized patients.1 , 2 , 5 To our knowledge the only reported case of pituitary tumor with elevated plasma ACTH . . .