Alpha and Beta Adrenergic Receptors in Human Veins; Activity of a New Beta-blocking Agent*

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Abstract
In the human venous bed NA [norepinephrine] is more active than A [epinephrine]: this situation is reversed when a new powerful beta-adrenergic blocking agent INPEA [N-isopropyl-l-(p-nitrophenyl) ethanolamine] Is used. This is shown by the authors using the venoconstriction test (VCT). Na and A sensitivity reversal from INPEA may be explained by the action of A on the alpha-receptors in the absence of any inhibitory effect due to simultaneous stimulation of the beta-receptors. The paradoxical arterial-hypotension and tachycardia from epinephrine, particularly evident in hypertensive subjects, is also antagonized by the beta-blockade with INPEA. Initial therapeutic trials are encouraging, particularly in angina pectoris.

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