Airway Response to Leukotriene D4 in Rhesus Monkeys
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 71 (2) , 156-160
- https://doi.org/10.1159/000233380
Abstract
We studied the effect of leukotriene D4 (LTD4) given by aerosol challenge on asthmatic and normal monkeys. The response to LTD4 occurred within 2 min., was prolonged at higher concentrations, was reversed by epinephrine, and more closely resembled an antigen response than a histamine response. Since LTD4 concentrations of 30–100 μg/ml produced a response similar to 2–20 mg/ml of histamine, the LTD4 was 300–900 times as potent as histamine on a molar basis. Thus, LTD4, which appears to reproduce an antigen-induced response in rhesus monkeys, may be a mediator of allergic asthma in these animals.Keywords
This publication has 2 references indexed in Scilit:
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- A study of the effect of slow-reacting substances of anaphylaxis on the rhesus monkey airwayJournal of Allergy and Clinical Immunology, 1978