Whole Body Transvascular Filtration Coefficient and Interstitial Space Capacitance

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Abstract
Infusion experiments with Ringer''s solution were performed on 5 splenectomized dogs with continuous monitoring of blood volume and hematocrit. The plasma volume was calculated from the data and followed during the infusion and the recovery period. Applying electrical equivalent simulation analysis to the result of the plasma volume, the capacitance of the interstitial fluid space and the transvascular filtration coefficient of water in the whole body were determined simultaneously. The mean values of the capacitance and the coefficient were 5.91 ml/kg-mmHg and 0.314 ml/min-kg-mmHg, respectively. A transfer function which predicts the fluid shift between the vascular system and the interstitial fluid space was derived. Using the transfer function, predictions of the changes in plasma volume are possible from any given rate of infusion.

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