Extraosseous Ewing's sarcoma. A study of 42 cases
Open Access
- 1 October 1989
- Vol. 64 (7) , 1548-1553
- https://doi.org/10.1002/1097-0142(19891001)64:7<1548::aid-cncr2820640733>3.0.co;2-w
Abstract
Fifty patients at the Mayo Clinic (Rochester, MN) from 1935 to 1985 met the histologic criteria for extraosseous Ewing's sarcoma. Forty-two had soft tissue primaries without bony involvement and formed the basis for this retrospective study of the clinical behavior and management of extraosseous Ewing's sarcoma. There were 19 male and 23 female patients (mean age, 22 years). Metastases were documented in 30 of the patients, six at the time of presentation and 24 occurring up to 11 years later, most commonly to lungs or bone. Three patients were lost to follow-up. Sixteen of 35 patients (46%) had local recurrence. Overall survival was 15 of 39 (38.5%) at 5 years. Decreased survival was noted with pelvic tumors, incomplete resections, and presence of metastatic disease, whereas increased survival was associated with wide surgical resection with negative microscopic margins, adjuvant local radiation therapy, and presentation since 1970 (48% 5-year survival compared with 28% before 1970).This publication has 17 references indexed in Scilit:
- Pathologic features of extraosseous Ewing's sarcoma: A report from the intergroup rhabdomyosarcoma studyHuman Pathology, 1988
- Extraosseous Ewing's sarcoma versus primitiverhabdomyosarcoma: Diagnostic criteria and clinical correlationHuman Pathology, 1986
- A System for the Surgical Staging of Musculoskeletal SarcomaClinical Orthopaedics and Related Research, 1980
- A clinicopathologic study of 20 cases of large-cell (atypical) Ewingʼs sarcoma of boneThe American Journal of Surgical Pathology, 1980
- Extraskeletal Ewingʼs sarcomaThe American Journal of Surgical Pathology, 1979
- So-called Extraskeletal Ewing’s Sarcoma: Report of a Case with Ultrastructural AnalysisAmerican Journal of Clinical Pathology, 1978
- Ewing's sarcoma of the spinal epidural space: report of two cases.Journal of Neurology, Neurosurgery & Psychiatry, 1978
- The intergroup rhabdomyosarcoma study (NIH): Objectives and clinical staging classificationJournal of Pediatric Surgery, 1975
- Paravertebral “Round Cell” Tumors in ChildrenRadiology, 1969
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958