Centrally administered non-NMDA but not NMDA receptor antagonists block peripheral knee joint inflammation
- 1 November 1993
- journal article
- Published by Wolters Kluwer Health in Pain
- Vol. 55 (2) , 217-225
- https://doi.org/10.1016/0304-3959(93)90150-n
Abstract
An experimental arthritis of the knee joint resulted in limping, guarding, and an increased response to heat stimuli (heat hyperalgesia). Spinal administration of the non-N-methyl-D-aspartate (non-NMDA) antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), significantly reduced the degree of peripheral inflammation, thermal and behavioral manifestations of arthritis. NMDA antagonists had no effect on the inflammation but did prevent the development of the heat hyperalgesia. Thus, central non-NMDA receptors play a major role in the development of peripheral inflammation while both non-NMDA and NMDA receptors are involved in the development of heat hyperalgesia.Keywords
This publication has 46 references indexed in Scilit:
- Neural changes in acute arthritis in monkeys. III. Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cordBrain Research Reviews, 1992
- Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acidsBrain Research Reviews, 1992
- Neural changes in acute arthritis in monkeys. II. Increased glutamate immunoreactivity in the medial articular nerveBrain Research Reviews, 1992
- Concentration of Substance P, Neurokinin A, Calcitonin Gene-related Peptide, Neuropeptide Y and Vasoactive Intestinal Polypeptide in Synovial Fluid from Knee Joints in Patients Suffering from Rheumatoid ArthritisScandinavian Journal of Rheumatology, 1991
- Substance p and arthritis: analysis of plasma and synovial fluid levelsArthritis & Rheumatism, 1990
- Peptide neuroanatomy of adjuvant-induced arthritic inflammation in ratInflammation Research, 1988
- Increase in extracellular potassium level in rat spinal dorsal horn induced by noxious stimulation and peripheral injuryBrain Research, 1988
- Inhibition of dorsal-horn cell responses by stimulation of the Kölliker-Fuse nucleusJournal of Neurosurgery, 1986
- Presynaptic inhibition in the vertebrate central nervous systemErgebnisse der Physiologie, Biologischen Chemie und Experimentellen Pharmakologie, 1970
- Primary Afferent Depolarization Evoked from the Sensorimotor CortexActa Physiologica Scandinavica, 1963