Relationships between Red Blood Cell Vitamin E and Polyunsaturated Fatty Acid in the Premature Infant

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Abstract
Low-birth-weight infants were fed breast milk (BM, n = 25) or 1 of 2 formulas containing 0.5 (PG, n = 32) or 1.7% fatty acids as α-linolenic acid (ALA)(ALA-PG, n = 31). Polyunsaturated fatty acids (PUFA) and α-tocopherol (αT) of RBC membrane phospholipids were measured at days 2 (D2) and 15 (D15) of enteral feeding, and at term. PUFA concentrations did not differ significantly between the 3 groups from D2 to term. The membrane integrity assessed by the αT/phospholipids ratio neither changed with time nor differed between formula groups. A metabolic relationship between αT and long-chain PUFA in RBC membranes was suggested by multiple regression analysis: αT showed a significant positive correlation with docosahexaenoic acid at D15 and term and with arachidonic acid at D15; the correlation with arachidonic acid tended toward significancy (p = 0.06) at term.

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