Serotonergic drug effects on a delayed conditional discrimination task in the rat; involvement of the 5-HT1A receptor in working memory

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Abstract
We investigated the effects of serotonergic drugs on working memory (WM) in a delayed conditional discrimination task. The 5-HT1A receptor full agonist flesinoxan (0.3-3.0 mg/kg) dose- and delay-dependently impaired performance, indicating a specific effect on WM. The 5-HT1A receptor partial agonist ipsapirone, the 5-HT 1B/1D/2C agonist TFMPP, the 5-HT1A antagonist NAN190 and the serotonin re-uptake inhibitor fluvoxamine dose-dependently impaired performance, in a delay-independent manner, indicating no specific effect on WM. The 5-HT 2 receptor antagonist ketanserin and the 5-HT3 receptor antagonist ondansetron did not affect performance. It is suggested that the role of central serotonin receptors in WM may be restricted to 5-HT1A receptors.