Ontogeny of Fc and Complement Receptors in Mouse Embryonic Tissues

Publisher Website
Google Scholar
Abstract
Mouse embryonic tissues [yolk sac, placenta, liver, spleen] were tested for their ability to form rosettes with EA [antibody-erythrocyte] and EAC [antibody-erythrocyte-complement] complexes. As early as the day after implantation (day 6) a small percentage of cells was able to bind both. After the 8th day of gestation the development of rosette-forming cells paralleled that of the immune system. The detection of Fc and C''3 [3rd component of complement] receptors on cells at least 2 days prior to the earliest known demonstration of lymphoid stem cells suggests that they may be expressed on cells other than those of the immune and phagocytic series.