Interferon Induction and Action in Human Lymphoblastoid Cells Infected with Measles Virus

Abstract
Virus replication, cytopathic effect and interferon production were measured in Namalva lymphoblastoid cells infected with measles viruses. Eight virus strains of different origin or passage history were compared. An inverse relationship seemed to exist between the abilities of strains to induce interferon and to replicate to high titers. Two representative strains were highly sensitive to lymphoblastoid cell interferon, when tested in a line of monkey kidney cells (Vero). Namalva cells were highly insensitive to autologous interferon when challenged with measles or Semliki Forest virus (SFV).

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