SC-29333: A potent inhibitor of canine gastric secretion

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Abstract
The gastric antisecretory effects of SC-29333, a novel prostaglandin E1 analog, were compared to the reference standard PGE1 methyl ester (PGE1ME) in gastric fistula and Heidenhain pouch dogs. Secretion was stimulated submaximally by continuous intravenous infusion of either histamine or pentagastrin. Meal-stimulated gastric secretory studies were also conducted. SC-29333 effectively inhibited volume, acid output, and pepsin secretion, in a dose-dependent manner. Intravenously (i.v.), SC-29333 was found to be approximately 30 times more potent than PGE1ME. The ranges of active i.v. bolus doses for SC-29333 and PGE1ME were 0.3–3.0 and 10–30 μg/kg, respectively. Unlike PGE1ME, SC-29333 was orally effective at doses of 10–30 μg/kg and was considerably better tolerated and longer acting than PGE1ME at active antisecretory doses. It is concluded, therefore, that SC-29333 is a potent, long-acting, orally effective inhibitor of gastric secretion in the dog.