Functionalised Pyrazoles through a Facile One-Pot Procedure from N-Tosyl-N-propargyl-hydrazine and Aryl Iodides or Vinyl Triflates
- 1 August 1997
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1997 (8) , 959-961
- https://doi.org/10.1055/s-1997-936
Abstract
Functionalised pyrazoles have been prepared in good overall yield through a facile one-pot procedure. The synthesis includes the palladium-catalysed coupling of the readily available N-tosyl-N-propargylhydrazine with aryl iodides or vinyl triflates, the palladium-catalysed annulation of the resulting N-tosyl-N-(1-aryl/vinyl-1-propyn-3-yl)hydrazine and exposure of the reaction mixture arising from the annulation step to KOBut.Keywords
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