The effects on epidermal DNA synthesis of topically applied cycloheximide
- 1 August 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 101 (2) , 163-166
- https://doi.org/10.1111/j.1365-2133.1979.tb05602.x
Abstract
An animal model [female A2hr mice] for investigating topically applied epidermal cytotoxic drugs to determine optimum therapeutic doses and schedules is described. It is used here to examine the effect of cycloheximide on epidermal DNA synthesis, as measured by 3H-thymidine incorporation in vivo, in terms of dose/response [for cutaneous malignancy and psoriasis] and activity/time profiles and potential systemic toxicity.This publication has 7 references indexed in Scilit:
- The treatment of cutaneous malignancies with topically applied cycloheximideBritish Journal of Dermatology, 1979
- The effects on epidermal DNA synthesis of the butyrate esters of clobetasone and clobetasol, and the propionate ester of clobetasolBritish Journal of Dermatology, 1978
- An animal model for evaluating the local and systemic effects of topically applied corticosteroids on epidermal DNA synthesisBritish Journal of Dermatology, 1978
- Topical Cycloheximide in PsoriasisJournal of Cutaneous Pathology, 1976
- An animal model for screening drugs for antipsoriatic properties using hydroxyapatite to isolate DNA rapidly from the epidermisBritish Journal of Dermatology, 1976
- An Animal Model For Screening Topical And Systemic Drugs For Potential Use In The Treatment Of PsoriasisJournal of Investigative Dermatology, 1975
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