PROGLUMIDE ANTAGONIZES THE STIMULATION OF RABBIT GALLBLADDER BY CHOLECYSTOKININ

  • 1 January 1984
    • journal article
    • research article
    • Vol. 269  (2) , 271-276
Abstract
Proglumide (3 .times. 10-4-3 .times. 10-3 M) produced parallel rightward shifts in the cumulative concentration-response curves for cholecystokinin octapeptide (CCK-8) in the rabbit gallbladder. Contractile responses to acetylcholine and serotonin were inhibited noncompetitively by the highest concentration of proglumide tested. K+-induced contractions were unaffected by proglumide. Proglumide may be used as a selective, competitive antagonist of the actions of CCK-8 in the isolated rabbit gallbladder preparation.

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