The First Regiospecific Synthesis of 8,8-Dimethyl-2H,8H-pyrano[2,3-h]quinolin-2-one and Related Compounds

Abstract
The title compound was synthesized in eight steps, starting from 6-acetamindo-2,3-dimethyl-2H-1-benzopyran-4-one (6). The key steps involved are the regiospecific nitration of 6 and palladium(0)-catalyzed arylation of acrylic acid in aqueous media.

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