Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster
- 9 May 2004
- journal article
- research article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 11 (6) , 558-566
- https://doi.org/10.1038/nsmb759
Abstract
In yeast cells, the THO complex has been implicated in mitotic recombination, transcription elongation and mRNA nuclear export. The stable core of THO consists of Tho2p, Hpr1p, Mft1p and Thp2p. Whether a complex with similar functions assembles in metazoa has not yet been established. Here we report that Drosophila melanogaster THO consists of THO2, HPR1 and three proteins, THOC5–THOC7, which have no orthologs in budding yeast. Gene expression profiling in cells depleted of THO components revealed that D. melanogaster.Keywords
This publication has 39 references indexed in Scilit:
- Molecular Evidence That the Eukaryotic THO/TREX Complex Is Required for Efficient Transcription ElongationJournal of Biological Chemistry, 2003
- Interactions between mRNA Export Commitment, 3′-End Quality Control, and Nuclear DegradationMolecular and Cellular Biology, 2002
- The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instabilityThe EMBO Journal, 2002
- TREX is a conserved complex coupling transcription with messenger RNA exportNature, 2002
- High-Copy-Number Expression of Sub2p, a Member of the RNA Helicase Superfamily, Suppresses hpr1-Mediated Genomic InstabilityMolecular and Cellular Biology, 2001
- A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiaeThe EMBO Journal, 2000
- RLR1 (THO2), required for expressing lacZ fusions in yeast, is conserved from yeast to humans and is a suppressor of SIN4Gene, 2000
- The Saccharomyces cerevisiae Hyperrecombination Mutant hpr1Δ Is Synthetically Lethal with Two Conditional Alleles of the Acetyl Coenzyme A Carboxylase Gene and Causes a Defect in Nuclear Export of Polyadenylated RNAMolecular and Cellular Biology, 1999
- A Complex Containing RNA Polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p Plays a Role in Protein Kinase C SignalingMolecular and Cellular Biology, 1999
- A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombinationThe EMBO Journal, 1998