Regulation of the APC and the exit from mitosis
- 1 June 1999
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 1 (2) , E47-E53
- https://doi.org/10.1038/10039
Abstract
The events of late mitosis, from sister-chromatid separation to cytokinesis, are governed by the anaphase-promoting complex (APC), a multisubunit assembly that triggers the ubiquitin-dependent proteloysis of key regulatory proteins. An intricate regulatory network governs APC activity and helps to ensure that late mitotic events are properly timed and coordinated.Keywords
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