Kidney and liver contributions to salicylate metabolism in rats
- 1 March 1994
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 19 (1) , 21-26
- https://doi.org/10.1007/bf03188818
Abstract
The pharmacokinetics and metabolism of radiolabelled salicylate were studied in rats and compared with that of the isolated perfused rat liver and the perfused rat kidney. Both parent compound and salicylate metabolites (mainly conjugates with glycine and glucuronic acid) were eliminated mostly into urine. The comparison of a relative proportion of metabolites eliminated in whole rats with that of the isolated perfused rat liver and the perfused rat kidney showed that both kidney and liver contributed to the salicylate metabolism. The glycine conjugate of salicylate was formed predominantly in the kidney whereas both kidney and liver participated in the formation of glucuronic acid derivatives.Keywords
This publication has 10 references indexed in Scilit:
- Tissue distribution of drug-metabolizing enzymes in humansXenobiotica, 1988
- The Effect of Molecular Structure on the Distribution and Elimination of Some Organic Acids in RatsQuantitative Structure-Activity Relationships, 1988
- Protein binding of tolfenamic acid in the plasma from patients with renal and hepatic diseaseEuropean Journal of Clinical Pharmacology, 1986
- Clinical Pharmacokinetics of the SalicylatesClinical Pharmacokinetics, 1985
- 99mTc complexes of ethylenediaminetetraacetic and ethylenediaminetetraacetohydroxamic acids; labelling and biodistributionInternational Journal of Nuclear Medicine and Biology, 1984
- A pharmacokinetic analysis program (multi) for microcomputer.Journal of Pharmacobio-Dynamics, 1981
- Pharmacokinetics of Salicylate in ManDrug Metabolism Reviews, 1979
- Renal Contribution to Overall Metabolism of Drugs II: Biotransformation of Salicylic Acid to Salicyluric AcidJournal of Pharmaceutical Sciences, 1972
- Relationship between Dose and Plateau Levels of Drugs Eliminated by Parallel First-Order and Capacity-Limited KineticsJournal of Pharmaceutical Sciences, 1972
- Pharmacokinetics of Salicylate Elimination in ManJournal of Pharmaceutical Sciences, 1965