Lucio's Phenomenon: Report of Two Cases and Review of the Literature

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Abstract
Involvement of the large arteries in patients with systemic sclerosis (SSc) has been only rarely reported. We describe the case of a 56-year-old woman with early diffuse cutaneous SSc who presented with acute unilateral digital ischemia. Evaluation identified thrombosis at the site of a previous subclavian-to-common carotid artery bypass, rather than Raynaud's phenomenon, as the cause of ischemia. A review of the literature indicates that large artery involvement, although a relatively uncommon clinical manifestation, can be frequently detected in the lower limbs as well as the ulnar arteries in patients with SSc.

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