The adrenoceptors mediating catecholamine effects in frog isolated skin

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Abstract
The short circuit current (s.c.c), potential difference (p.d.) and resistance of the frog skin have been studied. Sympathomimetics increased the s.c.c. in order of relative potency: isoprenaline > salbutamol > noradrenaline. The sympathomimetic-induced increase in s.c.c. was antagonized by propranolol and not by phentolamine. A large concentration of practolol was needed to antagonize the isoprenaline-induced increase in s.c.c. The antidiuretic hormone (ADH)-induced increase in s.c.c. was unaffected by propranolol, practolol or phentolamine. The results suggest that the sympathomimetic-induced increase in s.c.c. is mediated by β2-adrenoceptors.