Trimethoprim-sulfadiazine in the horse: Serum, synovial, peritoneal, and urine concentrations after single-dose intravenous administration
Open Access
- 1 April 1983
- journal article
- research article
- Published by American Veterinary Medical Association (AVMA) in American Journal of Veterinary Research
- Vol. 44 (4) , 540-543
- https://doi.org/10.2460/ajvr.1983.44.04.540
Abstract
SUMMARY: Six healthy adult mares were given a single iv injection of trimethoprim (tmp)-sulfadiazine (sdz) at a dosage rate of 2.5 mg of tmp/kg of body weight and 12.5 mg of sdz/kg. Serum, synovial, peritoneal, and urine tmp-sdz concentrations were measured serially over a 48-hour period. The highest measured mean concentrations of tmp and sdz were found in the first (0.5 hour) sample of serum, synovial fluid, and peritoneal fluid. The mean peak concentrations of tmp and sdz averaged 4.37 μg/ml and 21.81 μg/ml for serum, 2.95 μg/ml and 15.31 μg/ml for synovial fluid, and 3.88 μg/ml and 19.52 μg/ml for peritoneal fluid, respectively. Urine concentrations of the drugs were relatively high and peaked early. The elimination rate for tmp and sdz averaged 0.41 and 0.26 hour-1, while the elimination half-life was 1.91 and 2.71 hours, respectively, and the volume of distribution averaged 0.59 and 0.52 L/kg, respectively.This publication has 0 references indexed in Scilit: