Antihypertensive Treatment with the Adrenergic Beta-Receptor Blocker Metoprolol during Pregnancy
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 9 (4) , 195-204
- https://doi.org/10.1159/000300984
Abstract
In 101 hypertensive gravidae the selective Β-blocking agent metoprolol alone or in combination with hydralazine has been used. The effects of the mother and fetus have been compared with those of 97 hypertensive gravidae treated with hydralazine. In both groups a small dose of a thiazide was added. Perinatal mortality was lower in the metoprolol group (2.0%) than in the hydralazine group (8.0%). The rate of fetal growth retardations also was lower when using metoprolol (11.7 and 16.3%, respectively). No abnormal effects of the (Β-blocker was noticed on the fetus.Keywords
This publication has 1 reference indexed in Scilit: