Induction and augmentation of mitogen‐induced immune interferon production in human peripheral blood lymphocytes by Nα‐desacetylthymosin αl

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Abstract
Treatment of human peripheral blood lymphocytes with cloned Nα‐desacetylthymosin α1 induced interferon production. The kinetics is similar to that of mitogen‐induced interferon induction. Nα‐desacetylthymosin α1, in combination with mitogen, augments the amount of interferon produced. This interferon is immune interferon (IFN‐γ) as determined by sensitivity to pH 2, lack of neutralization by antibodies to IFN‐α or IFN‐β and absence of activity on MDBK cells. Although the mechanism of induction of IFN‐γ by Nα‐desacetylthymosin α1 is unclear, this compound is not mitogenic at concentrations causing IFN‐γ production. These results indicate that thymic factors may also participate in the regulation of IFN‐γ production.