The Metabolism of Alicyclic Ketones in the Rabbit and Rat
- 1 January 1971
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 1 (6) , 573-580
- https://doi.org/10.3109/00498257109112268
Abstract
1. Rabbits and rats dosed with cyclopentanone, cyclohexanone or cycloheptanone excrete traces of the corresponding 2-hydroxycycloalkylmercapturic acids. 2. In each case small amounts of a second sulphur-containing metabolite are excreted. Mass spectroscopic evidence suggests that these metabolites are the sulphate esters of 2-hydroxycycloalkylmercapturic acids. 3. Cyclopentyl and cycloheptyl glucuronides are the major metabolites of cyclopentanone and cycloheptanone in the rabbit.This publication has 20 references indexed in Scilit:
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