Amyloid colitis

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Abstract
Amyloidosis frequently involves the gastrointestinal tract and may result in a variety of symptoms, including those related to impaired motility, malabsorption and ulceration due to ischemia. The case of a 74 yr old man with systemic amyloidosis secondary to multiple myeloma is described, with striking gross morphologic findings involving the colon, seen at autopsy, resembling severe inflammatory bowel disease. Microscopically, the small arterioles of the lamina propria were markedly narrowed or occluded by massive deposition of amyloid, presumably leading to diffuse ischemia and mucosal necrosis. Although the radiologic appearance of this condition was well recognized and ischemia due to amyloidosis was described, this case is presented to demonstrate the gross anatomic changes not illustrated in previous reviews of the subject.

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