The effects of depolarization of motor nerve terminals upon the release of transmitter by nerve impulses

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Abstract
Depolarizing currents are applied to motor nerve terminals in the rat phrenic nerve-diaphragm muscle preparation in vitro. During the passage of depolarizing currents the amplitude of the presynaptic nerve action potentials and of end-plate potentials (e.p.p.s) was reduced in proportion to the current strength. The reduction in e.p.p. amplitudes was shown to be due to a reduction in the number of quanta released. An excess of Mg ions or the previous application of a hyperpolarizing current could prevent the reduction of e.p.p. amplitudes and quantal contents by depolarizing current. Depolarizing current application prevented later hyperpolarizing currents affecting e.p.p. amplitudes.