INHIBITION OF ACTOMYOSIN SUPERPRECIPITATION BY AN INDOLE DERIVATIVE OF EPINEPHRINE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 32  (3) , 473-486
Abstract
A zwitterion indole metabolite of epinephrine, an inhibitor of actomyosin ATPase, delayed or prevented superprecipitation of rat and rabbit cardiac and skeletal muscle actomyosin in a concentration-dependent manner. Inhibition of superprecipitation was not solely dependent on inhibition of actomyosin ATPase activity; apparently the ATPase inhibitor directly interfered with interaction of actin and myosin. Such an effect may occur by attachment of the indole derivative to free SH groups involved in actin-myosin association as previously postulated for inhibition of ATPase activity.

This publication has 2 references indexed in Scilit: