Reduced Behavioral Activity Due to Opiate Blockade: Relations to Stress

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Abstract
The effects of stress and opiate blockade [naltrexone] upon motor activity were parametrically examined in experimentally naive adult male Sprague-Dawley rats. Activity was not affected by either factor in isolation. It was reduced by their combined effect. This reduction was evident only after prolonged (60 min) prestress, suggesting that the decrement is not general. Previous reports of opiate blockade upon activity or exploration may have been due in part to implicity stressful or arousing aspects of testing procedures.