Effects of prostaglandin E1 and indomethacin on ACTH, prolactin, GH and LH from rat pituitary in vitro.

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Abstract
The effects of prostaglandin E1 (PGE1) and indomethacin (IDM) on the release of several pituitary hormones from the rat pituitary were investigated in vitro. Addition of 2 .mu.g/ml of PGE1 to the medium released growth hormone (GH) and prolactin, but not ACTH and luteinizing hormone (LH). Although the addition of 1 .mu.g/ml of IDM alone had no effect on the basal release of these hormones, IDM diminished the release of ACTH induced by crude rat hypothalamic extracts (HE) or lysine-8-vasopressin (LVP) and the release of LH induced by HE or luteinizing hormone-releasing hormone (LH-RH). A part of PGE1 action might be a direct action on the pituitary gland. PGE1 might release GH and prolactin, whereas IDM might have a direct action on the pituitary gland, which may blunt the release of these pituitary hormones induced by several stimuli.

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