Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT)
- 1 November 2000
- journal article
- review article
- Published by Wiley in Journal of Anatomy
- Vol. 197 (4) , 571-574
- https://doi.org/10.1046/j.1469-7580.2000.19740571.x
Abstract
Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3′-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.Keywords
This publication has 23 references indexed in Scilit:
- Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylationNature, 1999
- Essential Role for Protein Kinase B (PKB) in Insulin-induced Glycogen Synthase Kinase 3 InactivationJournal of Biological Chemistry, 1998
- Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response SequenceJournal of Biological Chemistry, 1998
- 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayGenes & Development, 1998
- The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegansNature, 1997
- Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling CascadesJournal of Biological Chemistry, 1997
- Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase AktScience, 1997
- Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)Oncogene, 1997
- Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 TranslocationJournal of Biological Chemistry, 1996
- The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.1995