Reduced Antibody Titers in Mice Treated with Carcinogenic and Cancer Chemotherapeutic Agents

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Abstract
A number of cancer chemotherapeutic agents, carcinogens and their noncarcinogenic analogs were tested for their effect on sheep cell hemolysin production in mice. All of the chemotherapeutic agents, with the exception of furacin, depressed the antibody titers. All of the carcinogens also produced a marked depression of the antibody levels but their non-carcinogenic analogs were without effect. None of the substances tested inhibited preformed antibodies in vivo or in vitro.