Cytogenetic Disorders

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Abstract
Over the past few years the importance of both acquired and constitutive cytogenetic disorders has become apparent, and we have begun to understand the nature of some of the acquired chromosomal abnormalities consistently found in various forms of cancer.In this issue of the Journal Han et al.1 suggest that patients with chronic lymphocytic leukemia who have B-cell clones with abnormal chromosomes have a poorer prognosis than those who have B-cell clones with normal karyotypes. The most frequent abnormality was found to be trisomy 12, either alone or in association with other chromosomal abnormalities. Prognosis as measured by duration of . . .