Failure of Cytotoxic Chemotherapy, 1983–1988, and the Emerging Role of Monoclonal Antibodies for Renal Cancer
- 1 January 1989
- journal article
- review article
- Published by S. Karger AG in Urologia Internationalis
- Vol. 44 (6) , 338-345
- https://doi.org/10.1159/000281537
Abstract
A review of 36 cytotoxic agents used singly in over 1,900 patients with renal cancer between 1983 and 1988 finds marginal antitumor activity, < 5–10%. The future role of monoclonal antibodies for therapy of this disease may offer some hope with the recent description of rather specific phenotypic expression, URO 10+/URO 8+, suggesting the cell origin of most renal tumors from the distal portion of the proximal tubule.Keywords
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