INFLUENCE OF CATECHOLAMINE-DERIVED ALKALOIDS AND BETA-ADRENERGIC BLOCKING-AGENTS ON STEREOSPECIFIC BINDING OF NALOXONE-H-3

  • 1 January 1977
    • journal article
    • research article
    • Vol. 17  (4) , 731-734
Abstract
Alkaloids containing a catecholamine moiety, tetrahydroisoquinolines and tetrahydroprotoberberines and a group of .beta.-adrenergic blocking agents were examined for their effects on the tritiated naloxone binding by rat brain homogenate. The stereospecific opiate antagonist binding was weakly inhibited by the catecholamine-derived alkaloids. The concentration of alkaloids producing 50% binding inhibition ranged from 0.06-0.37 mM. The inhibitory .beta.-adrenergic blocking agent effects appear to parallel their reported relative local anesthetic actions.