THE ANTIDYSRHYTHMIC AMINOSTEROID, ORG 6001, REDUCES THE ST‐SEGMENT ELEVATION PRODUCED BY CORONARY OCCLUSION IN THE DOG
Open Access
- 1 October 1977
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 61 (2) , 315-317
- https://doi.org/10.1111/j.1476-5381.1977.tb08421.x
Abstract
ST-segment elevation following temporary coronary artery occlusion was measured from nine epicardial leads in open-chest anaesthetized dogs. This was greatly reduced by the prior administration of the antidysrhythmic aminosteroid, ORG 6001. It is suggested that this effect is related either to a reduction in the extent and degree of myocardial ischaemia or to prevention of K+ egress from ischaemic cells.Keywords
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