ANIMAL-MODEL OF THE INSULIN-DEPENDENT DIABETES-MELLITUS IN BB RATS - THEIR RT1U HOMOGENEITY AND PROLONGED SURVIVAL OF ALLOGENEIC SKIN-GRAFTS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 30  (1) , 24-32
Abstract
Two substrains of BB rats spontaneously developing the insulin-dependent diabetes-like syndrome were studied. Both the partially inbred BB/K and randombred BB/DK substrains proved RT1u homozyogus. Their ancestral WOK stock was heterogeneous for the RT1u (f = 0.84) and RT1a (f = 0.16) haplotypes. Regarding the H-loci of the RT1 complex, the RT1 haplotype of BB rats seems not to be a recombinant between RT1u and RT1a from the ancestral WOK stock. The generally lowered immune responsiveness of BB recipients to allogeneic skin grafts might be caused by a mutation event at their RT1u haplotype or by some other major gene(s) from their genetic background.