Antagonistic Effect of Thiocarbanilide on 4,4'-Dinitrocarbanilide, A Component of Nicarbazin

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Abstract
Fifteen compounds, structurally similar to 4,4''-dinitrocarbanilide, were explored for antagonistic effect on the anticoccidial activity of nicarbazin. Thiocarbanilide, and 2 of its dichloro-substituted derivatives, effectively inhibited the anticoccidial activity of nicarbazin when given parenterally or orally in a 1 to 1 ratio. Thiocarbanilide also antagonized the effect of nicarbazin on the depigmentation of egg shell color. In both instances, the antagonistic effect of thiocarbanilide was correlated with decreased plasma concentrations of dinitrocarbanilide. Thiocarbanilide may interfere with the activity of nicarbazin through competition in absorption.

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