STEREOSELECTIVE INVERSION OF (R)-(-)-BENOXAPROFEN TO THE (S)-(+)-ENANTIOMER IN HUMANS
- 1 January 1979
- journal article
- research article
- Vol. 7 (6) , 356-359
Abstract
The enantiomeric composition of the potent active antiinflammatory agent benoxaprofen [(RS)-2-(p-chlorophenyl)-.alpha.-methyl-5-benzoxazoleacetic acid], in plasma and urine was determined after oral administration of both the racemic mixture and the (R)-(-)-enantiomer to normal human volunteers. Resolution of the diastereomeric amides, formed by the reaction of the enantiomers with (S)-(-)-.alpha.-methylbenzylamine, was accomplished by gas chromatography. The (R)-(-)-enantiomer of the parent drug was stereoselectively inverted to its (S)-(+) isomer in humans.This publication has 7 references indexed in Scilit:
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