An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
Top Cited Papers
Open Access
- 15 December 2007
- journal article
- Published by American Society of Hematology in Blood
- Vol. 110 (13) , 4427-4435
- https://doi.org/10.1182/blood-2007-05-090621
Abstract
Leukemia stem cells (LSCs) are thought to play a central role in the pathogenesis of acute leukemia and likely contribute to both disease initiation and relapseKeywords
This publication has 26 references indexed in Scilit:
- Constitutive Histone H2AX Phosphorylation and ATM Activation, the Reporters of DNA Damage by Endogenous OxidantsCell Cycle, 2006
- High Stem Cell Frequency in Acute Myeloid Leukemia at Diagnosis Predicts High Minimal Residual Disease and Poor SurvivalClinical Cancer Research, 2005
- The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancerMolecular Cancer Therapeutics, 2005
- Nuclear factor-κB inhibitors as sensitizers to anticancer drugsNature Reviews Cancer, 2005
- Characterization of acute lymphoblastic leukemia progenitor cellsBlood, 2004
- Mechanisms controlling pathogenesis and survival of leukemic stem cellsOncogene, 2004
- The transcription factor NF-κB: control of oncogenesis and cancer therapy resistanceBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2000
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- A cell initiating human acute myeloid leukaemia after transplantation into SCID miceNature, 1994
- Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow.The Journal of Experimental Medicine, 1992