Studies on pituitary polypeptide hormones. 1. The structure of β-melanocyte-stimulating hormone from pig pituitary glands

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Abstract
The [beta]-melanocyte-stimulating hormone from pig pituitary gland has been shown to be an octadecapeptide with the amino acid sequence shown. The heptapeptide Met.Glu.His.Phe.Arg.Try.Gly is also found in corticotropin. The tyrosine and proline residues in positions 5 and 15 respectively also occur in corresponding positions with respect to the common sequence in corticotropin, and but for the transposition of lysine and serine between positions 6 and 14 in [beta]-melanocyte-stimulating hormone the sequence common to both hormones would extend to 11 amino acids. These common structural features provide a chemical basis for the intrinsic melanocyte-stimulating activity of corticotropin.