Microbial 7-OH Epimerisation of Bile Acids
- 1 July 1999
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 28 (7) , 693-694
- https://doi.org/10.1246/cl.1999.693
Abstract
The microbial 7-OH epimerisation of cholic and chenodeoxycholic acids with Xanthomonas maltophilia CBS 827.97 to ursocholic and ursodeoxycholic acids with scarsity of oxygen is described. With normal pressure of oxygen the 7-ketocholic and the 7-ketochenodeoxycholic acids are obtained. No biotransformation is achieved in anaerobic conditions.This publication has 7 references indexed in Scilit:
- Regioselective microbial oxidation of bile acidsTetrahedron, 1998
- Biotransformations on steroid nucleus of bile acidsSteroids, 1997
- Clinical Pharmacokinetics of Therapeutic Bile AcidsClinical Pharmacokinetics, 1996
- Preparative-scale regio- and stereospecific oxidoreduction of cholic acid and dehydrocholic acid catalyzed by hydroxysteroid dehydrogenasesThe Journal of Organic Chemistry, 1986
- The Preparation of Chenodeoxycholic Acid and Its Glycine and Taurine Conjugates.Acta Chemica Scandinavica, 1963
- Preparation of Ursodeoxycholic Acid and 3alpha,7beta,12alpha-Trihydroxycholanic Acid. Bile Acids and Steroids 94.Acta Chemica Scandinavica, 1960
- Oxidation of Steroids. III. Selective Oxidations and Acylations in the Bile Acid Series1Journal of the American Chemical Society, 1950