Cardiac Studies in Patients Treated with Depsipeptide, FK228, in a Phase II Trial for T-Cell Lymphoma
Top Cited Papers
Open Access
- 15 June 2006
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 12 (12) , 3762-3773
- https://doi.org/10.1158/1078-0432.ccr-05-2095
Abstract
Purpose: The histone deacetylase inhibitor depsipeptide (FK228) has activity in patients with cutaneous or peripheral T-cell lymphoma. Electrocardiogram abnormalities, thought to be a class effect, were observed in preclinical animal studies and phase I testing and led to the incorporation of intensive cardiac monitoring in an ongoing efficacy trial.Keywords
This publication has 45 references indexed in Scilit:
- Phase I and Pharmacokinetic Study of MS-275, a Histone Deacetylase Inhibitor, in Patients With Advanced and Refractory Solid Tumors or LymphomaJournal of Clinical Oncology, 2005
- Effect of a Histone Deacetylase Inhibitor on Human Cardiac MassCardiovascular Drugs and Therapy, 2005
- T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistanceBlood, 2004
- Drug-Induced Prolongation of the QT IntervalNew England Journal of Medicine, 2004
- Effect of Arsenic Trioxide on QT Interval in Patients With Advanced MalignanciesJournal of Clinical Oncology, 2003
- The QT interval☆Progress in Cardiovascular Diseases, 2001
- Relations of QTc prolongation on the electrocardiogram to torsades de pointes: Definitions and mechanismsThe American Journal of Cardiology, 1993
- Measurement of the QT interval and the risk associated with QTc interval prolongation: A reviewThe American Journal of Cardiology, 1993
- An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study)The American Journal of Cardiology, 1992
- Real-Time Radionuclide Cineangiography in the Noninvasive Evaluation of Global and Regional Left Ventricular Function at Rest and during Exercise in Patients with Coronary-Artery DiseaseNew England Journal of Medicine, 1977