REPORT ON THERAPEUTIC PROPERTIES OF PENICILLIN: III. Surgery and Penicillin in Mandibular Infection

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Abstract
Penicillin is unlikely to give bacteriological control in the presence of sequestra or unfavorable surgical conditions; it is not a substitute for surgery. In 4 cases penicillin post-operatively caused rapid control of the infection without any undesirable local effects. Vascular disaster may play a dominant role in causation of bone infections and a technique of treatment of osteomyelitis of the jaw is descr. The adjuvant effect of penicillin has led to the conversion of the original open method to a closed one with all the advantages this confers. In the 16 cases so treated elimination of the penicillin-sensitive organisms, satisfactory soft-tissue healing, and good regeneration of the bone have taken place, so that recovery from what has hitherto been an extremely chronic condition has been effected in an av. of about 30 days.

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