Treatment of Nausea and Vomiting Related to Anti-Cancerous Multiple Combination Chemotherapy: Results of Two Controlled Studies
- 1 May 1978
- journal article
- research article
- Published by SAGE Publications in Journal of International Medical Research
- Vol. 6 (3) , 235-240
- https://doi.org/10.1177/030006057800600311
Abstract
Two controlled double-blind studies were carried out successively on a cancerous out-patient population receiving multiple combination chemotherapy at successive treatment courses to show the anti-emetic efficiency of metopimazine compared to a placebo. The patient was taken as his own control and the treatment, order was randomly selected. The first trial ▄ consisting of sixty-seven patients, showed a weak statistically significant difference (0.05 < p < 0.10) between metopimazine at doses of 30 mg/day or 15 mg/day and a placebo. The second trial ▄ comparing a higher dose of metopimazine (45 mg/day) among one hundred and sixteen patients, showed a highly statistically significant therapeutic advantage over a placebo (0.001 < p < 0.01).Keywords
This publication has 3 references indexed in Scilit:
- Controlled Clinical Studies of Orally Administered Antiemetic DrugsGastroenterology, 1969
- A Controlled Clinical Evaluation of Antiemetic DrugsJAMA, 1963