Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection
- 1 May 1985
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 315 (6017) , 301-305
- https://doi.org/10.1038/315301a0
Abstract
H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumor cells by the host immune system.This publication has 27 references indexed in Scilit:
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