The reaction between elastase and elastic tissue. 1. The substrate

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Abstract
Various methods were examined for the isolation of an entity, to which the name "elastin" can be applied. They were compared by observing changes produced in the susceptibility of the resulting material to attack by elastase. It is suggested that all existing methods for freeing so-called elastin from associated proteins are either inadequate or so drastic as to commence the degradation of the fundamental unit of elastic tissue ifself. For a study of elastic tissue, a series of alkali-treated preparations appear to offer the greatest scope. Further evidence is provided indicating that at least some of the "elastin" preparations which were described consist of more than one component, but in many of these the proportions differ considerably.