A direct comparison of the antigen‐specific antibody profiles of intravenous immunoglobulins derived from US and UK donor plasma

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Abstract
Background and Objectives Intravenous immunoglobulin (IVIG) is used in a range of immunodeficiency states that require a broad spectrum of protective antibodies to a range of common pathogens. A comparison of the antigen‐specific antibody profile of preparations of an IVIG (Vigam®) derived from US and UK sourced plasma was performed, and these preparations were also compared with three other IVIG products from different manufacturers.Materials and Methods Antibodies against a range of bacterial and viral pathogens were measured by immunoassay.Results Similar profiles were found for Vigam® made from UK and US source plasma and also for the other three IVIGs tested, but some specific differences were observed.Conclusions IVIG preparations have a similar therapeutic spectrum of antibodies when prepared from plasma sourced either from the UK or the US.