THE VASCULAR ACTION OF PILOCARPINE, ESERINE ADRENALINE AND ATROPINE, AND THEIR INFLUENCE IN PRIMARY CHRONIC GLAUCOMA

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Abstract
Atropine produces an arterial vasodilatation in the anterior uvea with a resultant decrease in the sum of resistances encountered by the blood and, therefore, a rise in the mean capillary pressure from which follows a rise in intraocular pressure. Pilocarpine and eserine produce a capillary vasodilatation but this causes an increase in the sum of resistances despite the increase of the vascular bed. There is, therefore, a decrease in the capillary pressure and in the intraocular pressure. Adrenaline produces both an arterial and a capillary vasodilatation but the latter effect is greater than the former. Adrenaline may, however, cause an increased capillary permeability to plasma proteins, and this will tend to raise the intraocular pressure.

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