COMPARATIVE STUDIES ON CENTRAL AND PERIPHERAL EFFECTS OF TWO EPIMERIC CATECHOLESTROGENS
- 1 November 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 109 (5) , 1799-1801
- https://doi.org/10.1210/endo-109-5-1799
Abstract
4-Hydroxyestradiol-17β and 4-hydroxyestradiol-17α(5 or 20 μg/d) were continuously s.c. infused for 3 days into ovariectomized adult rats. The serum levels of either epimer were virtually identical when the same dose was administered. 4-Hydroxyestradiol-17β significantly altered body and uterus weight and LH serum levels(negative and positive effects) at both doses tested. 4-Hydroxyestradiol-17α showed no effects even at the 20 ng/d dose. As both epimers have similar affinities for catechol O-methyltransferase,but their potencies regarding effects on LH serum levels differ markedly, it is concluded that the interaction of catecholestrogens with this enzyme is not essential for their effects on LH release.Keywords
This publication has 6 references indexed in Scilit:
- Radioimmunoassay for 4-hydroxyoestrone in human urineActa Endocrinologica, 1981
- Central and Peripheral Action of Estradiol and Catecholestrogens Administered at Low Concentration by Constant Infusion*Endocrinology, 1981
- Effect of low doses of continuously administered catecholoestrogens on peripheral and central target organsActa Endocrinologica, 1981
- Formation of 2- and 4-Hydroxyestrogens by Brain, Pituitary, and Liver of the Human Fetus*Journal of Clinical Endocrinology & Metabolism, 1978
- COMPARATIVE STUDIES ON THE METABOLISM OF OESTRADIOL IN THE BRAIN, THE PITUITARY AND THE LIVER OF THE RATActa Endocrinologica, 1978
- CATECHOL ESTROGEN FORMATION BY THE HUMAN FETAL BRAIN AND PITUITARYJournal of Clinical Endocrinology & Metabolism, 1976